judith-therrien-180x180

Judith Therrien

EDUCATION

Medical

1986-1991                                             MDCM, Faculty of Medicine McGill University Montreal, Quebec, Canada

Graduate                                 

 

1991-1994                                 Internal Medicine Specialty Training Department of Medicine McGill University      Montreal, Quebec, Canada

1994-1996                                 Cardiology Specialty Training Department of Cardiology   McGill University    Montreal, Quebec, Canada

 

Post-graduate training

 

1996-1997                                 Echocardiography Fellowship   Department of Cardiology Sir Mortimer B. Davis Jewish General Hospital McGill University Montreal, Quebec Canada

1997-1998                                 Clinical and Research Fellowship, Adult Congenital Heart Disease  Department of Cardiology The Royal Brompton Hospital London, England

1998-1999                                 Clinical and Research Fellowship, Adult Congenital Heart Disease Department of Cardiology The Toronto General Hospital Toronto, Ontario, Canada

 

 Professional Certifications

 

  • MDCM Degree, McGill University.
  • The American Board of Internal Medicine

 

June 26th, 1995                          Le College des Médecins du Quebec      Specialty Certificate in Internal Medicine

June 30th, 1995                          The Royal College of Physicians and Surgeons of Canada     Specialty Certificate in Internal Medicine.

November 2nd, 1996                   Le College des Medecins du Québec     Specialty Certificate in Cardiology

November 26th, 1996                  The Royal College of Physicians and Surgeons of Canada     Specialty Certificate in Cardiology

1997-1998                                 Clinical and Research Fellowship, Adult Congenital Heart Disease Department of Cardiology The Royal Brompton Hospital London, England

1998-1999                                 Clinical and Research Fellowship, Adult Congenital Heart Disease Department of Cardiology The Toronto General HospitalToronto, Ontario Canada

 

Research Activities

 

Past:  

The study of the right ventricular response to pulmonary valve replacement in adult patients with repaired Tetralogy of Fallot which led to identifying the best timing for pulmonary valve replacement in these patients. This has informed international guidelines and changed the way we practice world wide.

 

Current:

Bicuspid valve aortopathy. Its natural history, mechanism of dilatation in mice and response to medical therapy in humans. First multi center randomized trial on the effect of ARB and BB on aortic root dilatation in patients with bicuspid aortic valve. Trial is now finished, results are being analyzed.

The development of a Trans Aorto Pulmonary Stent in adult patients with end stage pulmonary hypertension. From simulated computer design to fabrication of the first and second generation stent to in vitro testing and in vivo pig experiments.

 

 

 

 

 Publications ( see Appendix A )

 

Peered Reviewed Articles

 

 

  1. Therrien J, Somerville Pregnancy and Congenitally Corrected Transposition of the Great Arteries. Am J Cardiol 1999;84:820-824.

 

  1. Therrien J, Gerlis L, Somerville Complex Pulmonary Atresia: Clinical Presentation and Mode of Death. Cardiology in the Young 1999;9:249-256.

 

  1. Therrien J, Webb GD, Gatzoulis M. Reversal of protein losing enteropathy with prednisone therapy in adult patients with modified Fontan operations: long term palliation or bridge to cardiac transplantation. Heart 1999;82:241-243.

 

  1. Therrien J, Henein MY, Li W, Somerville J, Rigby M. Right Ventricular Long Axis Function in Adults and Children with Ebstein’s Anomaly. Int J Cardiol 2000;73:243-9.

 

  1. Therrien J, Thorne S, Wright A, Kilner P, Somerville J. ** Repaired Coarctation- a “Cost Effective” Approach to Identify Complications in Adults. J Am Coll Cardiol (IF 16.50) 2000;35: 997-1002.

** Cited by 110 articles

 

  1. Therrien J, Webb GD, Siu S. **Pulmonary Valve Replacement in Adults Late after Repair of Tetralogy of Fallot : Are we Operating too Late ? J Am Coll Cardiol (IF 16.50) 2000;36:1670-5.

**Cited by 473 articles

 

  1. Fredriksen PM, Therrien J, Veldtman G, Warsi MA, Liu P, Siu S, Williams W, Granton J, Webb G. Lung function and aerobic capacity in adult patients following modified Fontan procedure. Heart 2001;85:295-9.

 

  1. Fredriksen PM, Chen A, Hechter S, Veldtman G, Therrien J, Webb, G. Exercise Capacity in Adult Patients with Congenitally Corrected Transposition of the Great Arteries. Heart 2001;85:191-5.

 

  1. Therrien J, Siu S, Gatzoulis M. **Impact of Pulmonary Valve Replacement on Arrhythmia Propensity Late after Repair of Tetralogy of Fallot. Circulation (IF 14.43) 2001;103:2489-94.

**Cited by 406 articles

 

 

  1. Hechter SJ, Fredriksen PM, Merchant N, Veldtman G, Straatman L, Therrien J, Warsi MA, Siu S, Benson L, Liu P, Webb G. Angiotensin Converting Enzyme Inhibitors in Adults with The Mustard Procedure. Am J Cardiol 2001;87:660-3.

 

  1. Fredriksen PM, Therrien J, Veldtman G, Warsi MA, Liu P, Webb G. **Lung function and aerobic capacity in adult with various congenital heart diseases. Am J Cardiol 2001;87:310-4.

** Cited by 174 articles

 

  1. *Sebbag I, Rudski L, Therrien J, Hirsch A, Langleben D. Effect of Chronic Infusion of Epoprostenol on the Echocardiographic Right Ventricular Myocardial Performance Index and its Relation to Clinical Outcome in Patients with Primary Pulmonary Hypertension. Am J Cardiol 2001;88:1060-3.

 

  1. Therrien J, Dore A, Gersony W, Iserin L, Liberthson R, Meijboom F, Colman JM, Oechslin E, Taylor D, Perloff J, Somerville J, Webb GD. Canadian Cardiovascular Society. CCS Consensus Conference 2001 update: recommendations for the management of adults with congenital heart disease. Part I. Can J Cardiol 2001;17:940-59.

 

  1. Therrien J, Gatzoulis M, Graham T, Bink-Boelkens M, Connelly M, Niwa D, Mulder B, Pyeritz R, Perloff J, Somerville J, Webb GD. Canadian Cardiovascular Society. CCS Consensus Conference 2001 update: recommendations for the management of adults with congenital heart disease. Part II. Can J Cardiol 2001;18:1029-1050.

 

  1. Therrien J, Warnes C, Daliento L, Hess J, Hoffmann A, Marelli A, Thilen U, Presbitero P, Perloff J, Somerville J, Webb GD. Canadian Cardiovascular Society. **CCS Consensus Conference 2001 update: recommendations for the management of adults with congenital heart disease. Part III. Can J Cardiol 2001;19:1135-1158.

**Cited by 216  articles

 

 

  1. *Malik P, Therrien J, Webb GD. Acute Myocardial Infarction Late After Mustard Procedure for Dextro-Transposition on the Great Arteries: Preventable with Long Term Systemic Anticoagulation? Can J Cardiol 2002;18:187-91.

 

  1. *Ghai A, Siu S, Harris L, Webb G, Therrien J. **Left Ventricular Dysfunction is a risk factor for sudden death in adults with repaired tetralogy of Fallot. J Am Coll Cardiol (IF 16.50) 2002;40:1675-80.

**Cited by 275  articles

 

 

  1. Therrien J, Morton P, Walker M, Grant J, Webb G. Controlled Trial of Exercise Rehabilitation in Patients with Tetralogy of Fallot Repair. Can J Cardiol 2003;19:685-89.

 

  1. *Varma C, Warr MR, Hendler AL, Narinder P, Webb GD, Therrien J. Prevalence of Silent Pulmonary Emboli in Adults after the Fontan Operation. J Am Coll Cardio (IF 16.50)  2003;41:2252-2258.

 

  1. *Silversides C, Veldtman G, Crossin J, Webb G, McCrindle B, Siu S, Therrien J. Pressure Half Time Correlates with Severity of Pulmonary Regurgitation in Adults with Repaired Tetralogy of Fallot. J Am Soc Echocardiogr 2003;16:1057-62.

 

  1. *Silversides C, Granton J, Hart M, Webb G, Therrien J. **Pulmonary Thromboembolic Disease in Adults with Eisenmenger Syndrome. J Am Coll Cardio (IF 16.50) 2003;42:1982-7.

**Cited by 105 articles

 

  1. *Benzaquen BS, Webb GD, Colman JM, Williams WG, Therrien J. Arterial Switch Operation After Mustard Procedures in Adult Patients with Transposition of the Great Arteries: Is it Time to Revise our Strategy? Am Heart J 2004;147(3):E8.

 

  1. *Salehian O, *Schwerzmann M, Merchant N, Webb GD, Siu SC, Therrien J. **Assessment of systemic right ventricular function in patients with transposition of the great arteries using myocardial performance index: comparison with cardiac magnetic resonance imaging. Circulation (IF 14.43) 2004;110:3229-33.

           ** Cited by 115 articles

 

  1. Therrien J, Provost Y, Colman J, Webb GD. **Normalization of Right Ventricular Volumes Following Pulmonary Valve Replacement in Adults After Repair of Tetralogy of Fallot: an MRI study. Am J Cardiol 2005;95:779-782.

** Cited by 421 articles

 

  1. *Salehian O,Horlick E, Schwerzmann M, Haberer K, McLaughlin P,. Siu SC, Webb G, Therrien J. **Improvements in Cardiac Form and Function Following Transcatheter Closure of Secundum Atrial Septal Defects. J Am Coll Cardiol (IF 16.50) 2005;45:499-504.

** Cited by 120 articles

 

  1. Therrien J, *Rhambihar S, Webb GD, Langleben D, Granton J. ASD Eisenmenger: Nature or Nurture? Can Journal Cardiol 2006;22:1133-6.

 

  1. *Schwerzmann M, Samman AM, Salehian O, Holm J, Merchant N, Webb G, Therrien J, Sui SC, Silversides CK. Comparison of echocardiographic and cardiac magnetic resonance imaging for assessing right ventricular function in adults with repaired tetralogy of Fallot. Am J Cardiol 2007;99:1593-7.

 

  1. *Alanbaei M, Jutras L, Therrien J, Marelli A. Iatrogenic cyanosis and clubbing: 25 years of chronic hypoxemia after the repair of an atrial septal defect. Can J Cardiol 2007;23:901-3.

 

  1. *Ahmed S, Honos G, Waling A D, Michel CM, Sebag IA, Rudski LG, Therrien J. Clinical course and echocardiographic predictors of aortic valve replacement in patients with bicuspid aortic valve. Journal of Am Soc Echo 2007;20:998-1003.

 

  1. *Tsang W, Bengt J, Salehian O, Holm J, Webb G, Therrien J. Intracardiac Thrombus in Adults with Fontan Operation: Treatment and Clinical Outcome. Cardiology in the Young, 2007; 17: 646-651.

 

  1. Khairy P, Harris L, Landzberg MJ, Viswanathan S, Barlow Am Gatzoulis MA, Fernancer SM, Beauchesne L, Therrien J, Chetaille P, Gordon E, Vonder Muhll I, Cecchin F. **Implantable cardioverter-defibrillators in tetralogy of Fallot. Circulation (IF 14.43) 2008;117:363-370.

** Cited by 246 articles

 

  1. Therrien J, Provost Y, Harrison J, Connelly M, Daemmerer H, Webb GD. Effect of Angiotensin Receptor Blockade on Systemic Right Ventricular Function and Size: a Multicenter, Double Blind, Randomized, Placebo-Controlled Clinical Trial. International Journal of Cardiology 2008;129:187-192.

 

  1. *Thanassoulis G, *Yip J, Jamorski M, Webb G, Siu S, Therrien J. Aortic Root Dilatation and Progression in Patients with Bicuspid Aortic Valve. Nature Clinical Practice Cardiovascular Medicine 2008; 5(12):821-8.

 

  1. Marelli AJ, Therrien J, Mackie AS, Ionescu-Ittu R, Pilote L. Planning the

Specialized care of adult congenital heart disease patients: from numbers to

Guidelines; an epidemiologic approach. Am Heart J 2009;157(1):1-8.

 

  1. Tzemos N, Therrien J, *Yip J, *Thanasoulis G, Tremblay S, Jamorski M, Webb G, Siu SC. Outcomes in Adult with Congenital Bicuspid Aortic Valves. JAMA (IF 35,289) 2008;300:1317-25.

** Cited by 277 articles

 

  1. Tzemos N, silversides CK, Colman JM, Therrien J, Webb GD, Mason J, Cocoara E, Sermer M, Sui SC. Late cardiac outcomes after pregnancy in women with congenital aortic stenosis. Am Heart J 2009;157:474-80.

 

  1. Mackie A, Ionescu-Ittu R, Therrien J, Pilote R, Marelli AJ. Children and adults with congenital heart disease lost to follow up:  who and when?  A population-based study. Circulation (IF 14.43) 2009;120:302-309.

 

  1. *Bouchardy J, Therrien J, Martucci G, Marelli A. **Atrial Arrhythmias in Adult with Congenital Heart Disease. Circulation (IF 14.43) 2009;120:1679-1686.

** Cited by 127 articles

 

  1. *Bernier M, Marelli A, Pilotte L, *Bouchardy J, Martucci G, Therrien J. Atrial Arrhythmias in Adults with Left vs. Right Congenital Heart Disease. Am J Cardiol 2010;106:547-551.

 

  1. Silversides CK, Marelli A, Beauchesne L, Dore A, Kiess M, Salehian O,Bradley T, Colman J, Connelly M, Harris L, Khairy P, Mital S, Niwa K,Oechslin E, Poirier N, Schwerzmann M, Taylor D, Vonder Muhll I, BaumgartnerH, Benson L, Celermajer D, Greutmann M, Horlick E, Landzberg M, Meijboom F,Mulder B, Warnes C, Webb G, Therrien J. Canadian Cardiovascular Society 2009 Consensus Conference on the Management of Adults with Congenital Heart. Executive Summary. Can J Cardiol. 2010;26(3): 143-150.

 

  1. Marelli A, Beauchesne L, Mital S, Therrien J, Silversides CK. Canadian Cardiovascular Society 2009 Consensus Conference on Management of Adults with Congenital Heart Disease. Introduction. Can J Cardiol. 2010;26(3):e65-e69.

 

  1. Silversides CK, Dore A, Poirier N, Taylor D, Harris L, Greutmann M, Benson L, Baumgartner H, Celermajer D, Therrien J. Canadian Cardiovascular Society 2009 Consensus Conference on the Management of Adults with Congenital Heart Disease: Shunt Lesions. Can J Cardiol 2010;26(3): e70-e79

 

  1. Silversides CK, Kiess M, Beauchesne L, Bradley T, Connelly M, Niwa K, Mulder B, Webb G, Colman J, Therrien J. **Canadian Cardiovascular Society 2009 Consensus Conference on the Management of Adults with Congenital Heart Disease: Outflow tract obstruction, coarctation of the aorta, tetralogy of Fallot, Ebstein anomaly and Marfan syndrome. Can J Cardiol 2010;26(3):e80-e97.

** Cited by 109 articles

 

  1. Silversides CK, Salehian O, Oechslin E, Schwerzmann M, Vonder Muhll I, Khairy P, Horlick E, Landzberg M, Meijboom F, Warnes C, Therrien J. Canadian Cardiovascular Society 2009 Consensus Conference on the Management of Adults with Congenital Heart Disease: Complex congenital cardiac lesions. Can J Cardiol. 2010; 26(3): e98-e117.

 

  1. *Do DH, Therrien J, Marelli A, Martucci G, Afilalo J, Sebag Right atrial size relates to right ventricular end-diastolic pressure in an adult population with congenital heart disease. Echocardiography 2011;28:109-16.

 

  1. *Lowe B, Therrien J, Martucci G, Marelli A. Diagnosis of pulmonary hypertension in the congenital heart disease adult population: impact on outcome. J Am Coll Cardiol (IF 16.50) 2011:58:538-46.

 

  1. *Afilalo J, Therrien J, Pilote L, Ionescu-Ittu R, Martucci G, Marelli AJ. Geriatric congenital heart disease: burden of disease and predictors of mortality. J Am Coll Cardiol (IF 16,50) 2011;58:1509-15.

 

  1. *Roifman I, Therrien J, Ionescu RI, Pilote L, *Kotowycz MA, Martucci G, Marelli AJ. Coarctation of the aorta and coronary artery disease: Fact or Fiction? Circulation (IF 14,43) 2012;126:16-21.

 

  1. Therrien J. “Pulmonary Valve Replacement Based Solely on Right Ventricular Size is Appropriate in the Asymptomatic Tetralogy Patient”. Progress in Ped Cardiol 2012;34:31-35.

 

  1. Beauchesne LM, Therrien J, Alvarez N, Bergin L, Burggraf G, Chetaille P, Gordon E, Kells CM, Kiess M, Mercier LA, Oechslin EN, Stein J, Tam JW, Taylor D, Williams A, Khairy P, Mackie AS, Silversides CK, Marelli AJ. Structure and process measures of quality of care in adult congenital heart disease patients: a pan-Canadian study. International Journal of Cardiology 2012;157(1):70-4.

 

  1. *Kotowycz MA, Therrien J, Ionescu-Ittu R, *Owens C, Martucci G, Tchervenkov C, Pilote L, Marelli AJ Long-Term Outcomes After Surgical vs. Transcatheter Closure of Atrial Septal Defects in Adults. JACC Intervention 2013;6:497-503.

 

  1. *Bouchardy J; Marelli AJ; Martucci G; Bottega N; Therrien J. Mirror image atrial dilatation in adult patients with atrial fibrillation and congenital heart disease. International Journal of Cardiology 2013;167:816-20.

 

  1. *Guo K, Martucci G, Leask R, Marelli A, Shimony A, Langleben D, Afilalo J,Therrien J. Anatomical considerations for the development of a new transcatheter aortopulmonary shunt device in patients with severe pulmonary arterial hypertension. Pulmonary Circulation, 2013; 3(3): 639–646.

 

  1. Rushani D, Kaufman JS, Ionescu-Ittu R, Mackie AS, Pilote L, Therrien J, Marelli AJ. Infective endocarditis in children with congenital heart disease: cumulative incidence and predictors. Circulation (IF 14.43) 2013;128:1412-9.

 

  1. Zomer AC, Ionescu-Ittu R, Vaartjes I, Pilote L, Mackie AS, Therrien J, Langemeijer MM, Grobbee DE, Mulder BJ, Marelli AJ. Sex differences in hospital mortality in adults with congenital heart disease: the impact of reproductive health. J Am Coll Cardio (IF 16.50) 2013;62:58-67.

 

  1. *Addetia K, Sebag IA, Marelli A, Do DH, Afilalo J, Martucci G, Therrien J. Right ventricular end-diastolic wall stress: does it impact on right atrial size, and does it differ in right ventricular pressure vs. volume loading conditions?. Canadian Journal of Cardiology 2013; 29:858-65.

 

  1. *Mylotte D, Pilote L, Ionescu-Ittu R, Abrahamowicz M, Khairy P, Therrien J, Mackie AS, Marelli A. Specialized adult congenital heart disease care: the impact of policy on mortality. Circulation (IF 14.43) 2014;129:1804-12.

 

 

  1. *Mylotte D, Quenneville SP, Kotowycz MA, Xie X, Brophy JM, Ionescu-Ittu R, Martucci G, Pilote L, Therrien J, Marelli AJ. Long-term cost-effectiveness of transcatheter versus surgical closure of secundum atrial septal defect in adults. International Journal of Cardiology 2014;172:109-14.

 

  1. Wald RM, Altaha MA, Alvarez N, Caldarone CA, Cavalle-Garrido T, Dallaire F, Drolet C, Grewal J, Hancock Friesen CL, Human DG, Hickey E, Kayedpour C, Khairy P, Kovacs AH, Lebovic G, McCrindle BW, Nadeem SN, Patton DJ, Redington AN, Silversides CK, Tham EB, Therrien J, Warren AE, Wintersperger BJ, Vonder Muhll IF, Farkouh ME.Rationale and design of the Canadian Outcomes Registry Late After Tetralogy of Fallot Repair: the CORRELATE study. Canadian Journal of Cardiology 2014;30:1436-43.

 

  1. *Nanci Vanessa, Judith Therrien, Mohammed Kaouache, Darren Mylotte, Ariane Marelli. Predictors of Emergency Department Visits among Adult Congenital Heart Disease Patients: A Population-Based Analysis. J Am Coll Cardiol (IF 16.50) 2014;63(12_S):. doi:10.1016/S0735 1097(14)60604-5.

 

  1. Boodhwani M, Andelfinger G, Leipsic J, Lindsay T, McMurtry MS,Therrien J, Siu SC. Canadian Cardiovascular Society position statement on the management of thoracic aortic disease. Canadian Journal of Cardiology 2014;30:577-89.

 

  1. Broberg, CS, Therrien J. “Understanding and treating aortopathy in bicuspid aortic valve.” Trends in cardiovascular medicine 2015;5:445-451.

 

  1. *Lanz J, Brophy JM, Therrien J, Kaouache M, Guo L, Marelli AJ. Stroke in Adults with Congenital Heart Disease: Incidence, Cumulative Risk, and Predictors. Circulation (IF 14.43) 2015;132:2385-2394.

 

  1. *Albualsaud A, *Guo K, *Boris L, Marelli A, Jutras L, Martucci G, Therrien J. Cardiac output as a predictor in congenital heart disease: Are we stating the obvious? Int J Cardio 2016;201:143-8.

 

  1. Renaud C, El Rayes M, Ordonez M, Marelli A, Therrien J. “Risk of Stroke in Patients with Right sided Congenital Heart Disease”. Submitted to Porgress in Pediatric Cardiology 2016.

 

 

 

 

 

Review Articles

 

 

  1. Therrien J, Marreli AJ. Medical Management of Cyanotic Congenital Heart Disease in Adults. Contemporary Treatment in Cardiovascular Disease 1997;2:227-240.

 

  1. Therrien J, Connelly MS, Webb GD. Treatment strategies for isolated patent ductus arteriosus in the adults. Current Treatment Options in Cardiovascular Medicine 1999,1:341-346.

 

 

  1. Therrien J, Webb G. Clinical update on adults with congenital heart disease. The Lancet 2003;362 :1305-13.

 

 

Chapters

 

 

  1. Therrien J, Webb GD, Chapter 44. Adult Congenital Heart Disease, Braunwald, 6th 2001.

 

  1. Therrien J, Gatzoulis MA, Marx GR. Late Problems in Tetralogy of Fallot- Recognition, Management, and Prevention. Cardiology Clinics 2002;20:395-404.

 

  1. Therrien J. Chapter 5 Echocardiography, Diagnosis and Management of Adult Congenital Heart Disease, 1rst 2003.

 

  1. Redington A, Smallhorn J, Therrien J, Webb GD, 44 Congenital Heart Disease, Braunwald, 7th Ed. 2004.

 

  1. Therrien J. Chapter 4, Cases in Adult Congenital Heart Disease, First edition, 2007.

 

  1. Therrien J. Chapter 4. LVOT obstruction. American College of Cardiology Echo SAP 5,

 

  1. Redington A, Smallhorn J, Therrien J, Webb GD, 61 Congenital Heart Disease, Braunwald, 8th Ed. 2007.

 

  1. Martucci G, Therrien J. Chap 32.Timing and outcome of surgical pulmonary valve replacement. Congenital Diseases in the Right Heart, 1 RST 2009.

 

  1. Mackie AS, Therrien J. Chapter 11. Mechanisms of Late Systemic Right Ventricular Failure. Congenital Diseases in the Right Heart, 1 RST 2009.

 

  1. Therrien J. Chap 10. TOF chapter in Adult Congenital Heart Disease 2009.

 

  1. Therrien J. Chapter 4. LVOT obstruction. American College of Cardiology Echo SAP6,

 

  1. Redington A, Smallhorn J, Therrien J, Webb GD, Chapter 65 Congenital Heart Disease, Braunwald, 9th 2011.

 

  1. Redington A, Smallhorn J, Therrien J, Webb GD, Chapter 65 Congenital Heart Disease, Braunwald, 10th 2013.

 

  1. Redington A, Smallhorn J, Therrien J, Webb GD, Chapter 65 Congenital Heart Disease, Braunwald, 11th 2016.

 

  1. J Therrien, Perloff JK, Marelli A. Chapter 2, Approach to Congenital Heart Disease, Diagnosis and Management of Adult Congenital Heart Disease, 3rd 2016.

 

 

 

TEXTBook

 

  1. Gatzoulis MA, Swan L, Therrien J, Pantely Adult Congenital Heart Disease: A Practical Guide. BMJ. Ed Blackwell, 2005. (Translated in Spanish, Italian, Greek and Chinese).

 

 

Letter

 

 

  1. Therrien J, Williams W, Webb G. J Am Coll Cadiol 2001;37:2008-7.

 

 

 

Clinical Pictures in Medicine

 

 

1.             *Benzaqien B, Therrien J. Thoracic aortic aneurysm occurring at a coarctation repair site. Can J Cardiol 2003;19:561-2.

 

  1. Nguyen V, Benzason M, Michel C, Therrien J. Right Atrioventricular Groove Hematoma. Can J Cardiol 2004;21:91.

 

  1. *Addetia K, Therrien J. Spot diagnosis using pulse wave Doppler interrogation of the abdominal aorta. J Cardiovasc Ultrasound 2012;20(2):112-113.

Abstracts

 

 

  1. Therrien J, Somerville Pregnancy and Congenitally Corrected Transposition of the Great Arteries. Heart 1998;79[suppl 1]:82.

 

  1. Therrien J, Siu S, Gatzoulis M. Pulmonary Valve Replacement Stabilizes QRS Duration Late after Repair of Tetralogy of Fallot. Can J Cardiol 1999;15[suppl D]:203D.

 

 

  1. Therrien J, Siu S, Gatzoulis M. Pulmonary Valve Replacement Stabilizes QRS Duration Late after Repair of Tetralogy of Fallot. J Am Coll Cardiol 2000;35[suppl A]:512A.

 

  1. Therrien J, Webb GD, Siu S. Pulmonary Valve Replacement in Adults Late after Repair of Tetralogy of Fallot : Are we Operating too Late ? J Am Coll Cardiol 2000;35[suppl A]:509A.

 

  1. Fredriksen PM, Therrien J, Veldtman G, Warsu MA, Liu P, Webb G. Differences in physical performance in right atrium to right ventricular conduit as compared to right atrium to pulmonary artery connection in adult patients with modified Fontan procedure. J Am Coll Cardiol 2000;35[suppl A]:498A.

 

  1. Therrien J, Morton P, Walker M, Grant J, Webb G. Exercise Rehabilitation in Patients with Tetralogy of Fallot Repair. Can J Cardiol 2000;16[suppl F]:177.

 

  1. Hechter SJ, Fredriksen PM, Merchant N, Veldtman G, Straatman L, Therrien J, Warsi MA, Siu S, Benson L, Liu P, Webb G. Angiotensin Converting Enzyme Inhibitors in Adults with The Mustard Procedure. Can J Cardiol 2000;16[suppl F]:179.

 

  1. Therrien J, Morton P, Walker M, Grant J, Webb G. Controlled Trial of Exercise Rehabilitation in Patients with Tetralogy of Fallot Repair Pediatric World Congress

 

  1. Veldtman GR, Chan KYH, Gomperts NR, Meijboom L, Merchant N, Therrien J, Webb GD. Clinical Characteristics of Adult Marfan Syndrome Patients who Fulfill the 1986 Gent Criteria Pediatric World Congress 2001.

 

  1. *Sebbag I, Rudski L, Therrien J, Hirsch A, Langleben D. Effect of Chronic Infusion of Epoprostenol on the Echocardiographic Right Ventricular Myocardial Performance Index and its Relation to Clinical Outcome in Patients with Primary Pulmonary Hypertension. ASE 2001

 

  1. Veldtman GR, Silversides C, Webb GD, Therrien J, Merchant N, Siu S, McCrindle B. Should we use 2-D echo in the assessment of right ventricular form and function in adults with repaired Tetralogy of Fallot or Pulmonary Atresia? J Am Coll Cardiol 2002

 

  1. *Ghai A, Silverside C, Harris L, Webb G, Siu S, Therrien J. Left Ventricular Dysfunction is a risk factor for sudden death in adults with repaired tetralogy of Fallot. CJC 2002

 

  1. *Yip J, *Thanassoulis G, Jamorski M, Webb G, Siu S, Therrien J. Aortic Root Dilatation and Progression in Patients with Bicuspid Aortic Valve with or without Coarctation of the Aorta. CJC 2002

 

  1. *Yip J, *Thanassoulis G, Jamorski M, Webb G, Siu S, Therrien J. Aortic Root Dilatation and Progression in Patients with Bicuspid Aortic Valve with or without Coarctation of the Aorta. ACC 2003

 

  1. *Varma C, Warr MR, Hendler AL, Narinder P, Webb GD, Therrien J. Prevalence of Silent Pulmonary Emboli in Adults after the Fontan Operation. ACC 2003.

 

  1. Kuliszewski MmA, Zucco L, Faughnan M, Therrien J, Sterwart DJ, Kutryk MJB. Phenotypic Characterization of Circulating Endothelial Progenitor Cells in Genetically Determined Vascular Disorders. AHA 2003

 

  1. Therrien J, Provost Y, Colman J, Webb GD. Normalization of Right Ventricular Volumes Following Pulmonary Valve Replacement in Adults After Repair of Tetralogy of Fallot: an MRI study. ACC 2004

 

  1. *Salehian O, Therrien J. RVMPI on echocardiography correlated with RVEF on MRI for systemic RV. ASE 2004.

 

  1. Therrien J, *Rhambihar S, Webb GD, Langleban D, Granton J. ASD Eisenmenger: Nature or Nurture? AHA 2004

 

  1. *Tsang W, Bengt J, Salehian O, Holm J, Webb G, Therrien J. Intracardiac Thrombus in Adults with Fontan Operation: Treatment and Clinical Outcome. AHA 2004.

 

  1. Zucco L, Duliszewski MA, Horlick E. Swan L, Therrien J, Stewart DJ, Kutryk. Abnormalities in function and phenotype of circulating endothelial progenitor cells have been found in patients with aortic coarctation. CCS 2004

 

  1. Marelli AJ, Therrien J, Mackie AS, Ionescu-Ittu R, Pilote L. Planning for the Future of Adult Congenital Heart Disease Patients: From Numbers to Guidelines.  Can J of Cardiol, 2006; 22 (Suppl D):

 

  1. Marelli AJ, Therrien J, Mackie AS, Ionescu-Ittu R, Pilote L. Planning for the Future of Adult Congenital Heart Disease Patients:  From Numbers to Guidelines.  Circulation 2006;  114(18) (Suppl II):  11-681.

 

  1. *Do DH, Therrien J, Marelli A, Martucci G, Sebag I. Right atrial size relates to invasive markers of chronic diastolic dysfunction in an adult population with congenital heart disease. World Society for Pediatric and Congenital Heart Surgery, May 3-4, 2007.

 

  1. Mackie A, Ionescu-Ittu R, Therrien J, Pilote R, Marelli AJ. Children and adults with congenital heart disease lost to follow up:  who and when?  A population-based study. J Am Coll Cardiol 2007; 268A.

 

  1. *Bouchardy J, Therrien J, Martucci G, Marelli A. Atrial Fibrillation Doubles Adverse Events in Adult with Congenital Heart Disease: A Population Based Study From 1983 to 2005. J Am Coll Cardiol 2008; 51: A83.

*Outstanding Research Award International Symposium on ACHD.

 

  1. *Bouchardy J, Therrien J, Martucci G, Marelli A. Atrial Fibrillation Doubles Adverse Events in Adult with Congenital Heart Disease: A Population Based Study From 1983 to 2005. Societe Suisse Cardiologie 2008

 

  1. *Bouchardy J, Therrien J, Martucci G, Marelli A. Atrial Fibrillation Doubles Adverse Events in Adult with Congenital Heart Disease. International Toronto ACHD meeting 2008

 

  1. Silversides C, Therrien J, Oechslin E, A contemporary perspective on Eisenmenger syndrome in adults: a multicentre study. International Toronto ACHD meeting 2008

 

  1. *Do DH, Therrien J, Marelli A, Martucci G, Sebag I. Right atrial size relates to invasive markers of chronic diastolic dysfunction in an adult population with congenital heart disease. International Toronto ACHD meeting 2008

 

  1. Silversides CK, Connelly M, Mercier LA, Therrien J, Vonder Muhll I, Kiess M, Beauchesne LM, Rodes J, Alharbi M, Gordon E, Tam MJ, Dias B, Burggraf G, Oechslin EN. A Contemporary Perspective on Eisenmenger Syndrome in Adults: A Multicenter Study. Can J Cardiol 2008;24:Suppl 4, 209E.

 

  1. Bottega N, Shang S, Ionescu-Ittu R, Therrien J, Martucci G, Pilote L, Marelli A. “Rising Number of Pregnancies and Offspring in Women with Congenital Heart Disease: A Population-Based Study”. Circulation 2008; 118 S-929

 

  1. Beauchesne LM, Therrien J, Alvarz N, Bergin L, Burgraff G, Chetaille P, Gordon E, Kells C, Kiess M, Mercier L, Oeschslin EN, Stein J, Tam JW, Taylor D, Williams A, Marelli A. “Status of Adults Congenital Heart Disease Clinics in Canada: A Survey on Infrastructure, Resources and Clinical Volumes”. Circulation 2008;118(Suppl I8):S929.

 

  1. *Lowe B, Therrien J, Martucci G, Marelli A. Effect of Pulmonary Hypertension on Mortality and Morbidity in Adult Patients with Congenital Heart Disease: A Population Study. J Am Coll Cardiol 2009; 53 A355-A36.

 

  1. *Bernier M, Marelli A, Pilotte L, *Bouchardy J, Martucci G, Therrien J. Atrial Fibrillation in Adults with Congenital Heart Disease: Does Right vs. Left Cardiac Pathology Matter? J Am Coll Cardiol 2009: 53 A355-A36.

 

  1. *Bouchardy J, Marelli A, Martucci G, Therrien J. Mirror Image Atrial Dilatation in Adult Patients with Congenital Heart Disease and Atrial Fibrillation. 5th World Congress of Pediatric Cardiology and Cardiac Surgery. Australia, June 21, 2009.

 

  1. *Lowe B, Marelli A, Martucci G, Therrien J. Adult Congenital Heart Disease: the Right Gone Wrong. 5th World Congress of Pediatric Cardiology and Cardiac Surgery. Australia, June 21, 2009.

 

  1. *Do H, Therrien J, Marelli A, Martucci G, *Afilalo J, Sebag I. Clinical Utility of Right Atrial Size by Echocardiography in the Assessment of Right Ventricular End Diastolic Pressure. Journal American Echo Society 2009;22:585.

 

  1. *Bouchardy J, Marelli A, Martucci G, Therrien J. Mirror Image Atrial Dilatation in Adult Patients with Congenital Heart Disease and Atrial Fibrillation. Eur Heart J 2009; 30 (suppl 1): 802.

 

  1. *Affilalo J, Therrien J, Pilote L, Martucci G, Marelli A. Adults with congenital Heart Disease, a Geriatric Perspective. Circulation 2009; 120 S-562

*Outstanding Research Award Association des Cardiologues du Quebec

 

  1. *Shamez S, *Lowe B, Jutras L, Marelli A, Therrien J. Pulmonary Regurgitant volume vs. Fraction: a Matter of Restrictive Physiology. Circulation 2009; 120 S-582

 

  1. *Shamez S, *Lowe B, Jutras L, Marelli A, Therrien J. Pulmonary Regurgitant volume vs. Fraction: a Matter of Restrictive Physiology. Accepted for Europe Society of Echocardiography Madrid  2009

 

  1. *Owens CG, Therrien J, *Kotowycz MA, Martucci G, Ionescu RI, Pilote L, Dancea A, Tchervenkov C, Marelli AJ. Long Term Follow-up of Children Undergoing Transcatheter vs. Surgical Closure of Atrial Septal Defect – A Population Based Study. Irish Society 2010

 

  1. *Owens CG, Therrien J, *Kotowycz MA, Martucci G, Ionescu RI, Pilote L, Dancea A, Tchervenkov C, Marelli AJ. Long Term Follow-up of Children Undergoing Transcatheter vs. Surgical Closure of Atrial Septal Defect – A Population Based Study. Canadian Journal of Cardiology 2010; 26 (Supp D):74D.

 

  1. *Owens CG, Therrien J, *Kotowycz MA, Martucci G, Ionescu RI, Pilote L, Dancea A, Tchervenkov C, Marelli AJ. Long Term Safety of Children Undergoing Transcatheter vs. Surgical Closure of Atrial Septal Defect – A Population Based Study. Circulation 2010; 122:A21439.

      *With AHA press release and two 30 min interviews requested

 

  1. *Kotowycz MA, Therrien J, Ionescu-Ittu R, *Owens C, Martucci G, Tchervenkov C, Pilote L, Marelli AJ Long-Term Outcomes After Surgical vs. Transcatheter Closure of Atrial Septal Defects in Adults Accepted oral presentation AHA 2010. Circulation 2010; 122:A17482

 

  1. *Roifman I, Therrien J, Ionescu RI, Pilote L, *Kotowycz MA, Martucci G, Marelli AJ. Coarctation of the aorta and coronary artery disease: Fact or Fiction? J Am Coll Cardiol 2011;57:E 408.

 

  1. Quenneville SP, Xie X, Brophy JM, *Kotowycz MA, Pilote L, Therrien J, Ionescu-Ittu R, Martucci G, Marelli A. Cost effectiveness of transcatheter versus surgical closure of secundum atrial septal defect in adults: a population-based analysis. J Am Coll Cardiol 2011; 57: E461.

 

  1. *Owens CG, Therrien J, *Kotowycz MA, Martucci G, Ionescu RI, Pilote L, Dancea A, Tchervenkov C, Marelli AJ. Long Term Safety of Children Undergoing Transcatheter vs. Surgical Closure of Atrial Septal Defect – A Population Based Study. International ACHD Conference, Cincinnati , June 2011.

 

  1. *Roifman I, Therrien J, Ionescu RI, Pilote L, *Kotowycz MA, Martucci G, Marelli AJ. Coarctation of the aorta and coronary artery disease: Fact or Fiction? International ACHD Conference, Cincinnati , June 2011.

 

  1. *Addetia K, Sebag I, Marelli A, Martucci G, Therrien J. Right Ventricular End Diastolic Wall Stress: a new Marker for Right Ventricular Dysfunction. International ACHD Conference, Cincinnati , June 2011.

 

  1. *Bouchardy J, Marelli A, Martucci G, Therrien J. Mirror Image Atrial Dilatation in Adult Patients with Congenital Heart Disease and Atrial Fibrillation. International ACHD Conference, Cincinnati , June 2011.

 

  1. Ariane Marelli, Raluca Ionescu-ittu, Michal Abrahamowicz, Paul Khairy, Judith Therrien, Andrew Mackie, Tao Gao, Louise Pilote. Adult Congenital Heart Disease Centre Care: A Population Based Analysis of Impact on Mortality. Circulation 2011; 124:A12115

 

  1. *Zei A, *Addetia K, Langleben D, Therrien J. “Clinical Utility of Right Ventricular End-Diastolic Wall Stress in Patients with Pulmonary Hypertension” AHA 2012.

 

  1. *Zei A, *Addetia K, Langleben D, Therrien J. “Clinical Utility of Right Ventricular End-Diastolic Wall Stress in Patients with Pulmonary Hypertension” CCS 2012.

 

  1. *Addetia Karima, Giuseppe Martucci, Adrian Dancea, Ariane Marelli, and Judith Therrien. “Percutaneous vs. Surgical Pulmonary Valve Implantation: How Does the Right Ventricle Fare?.” Circulation 126, no. 21 Supplement (2012): A9635.

 

  1. Rushani, Dinela, Jay S. Kaufman, Andrew Mackie, Louise Pilote, Judith Therrien, and Ariane Marelli. “Cumulative risk of Infective Endocarditis in Children with Congenital Heart Disease – a Population Based Study”. Journal of the American College of Cardiology 59, no. 13s1 (2012): E819-E819.

 

  1. *Guo K, Therrien J.Anatomical Considerations for the Development of a new Transcatheter Aortopulmonary Shunt Device in Patients with Severe Pulmonary Arterial Hypertension”. McGill research Day 2012.

 

  1. *Guo, Kenneth Wei Qiang, Ariane Marelli, Mohammed Kaouache, and Judith Therrien. “Blood Transfusion: a Novel Culprit of Early Graft Failure in Children?.” Journal of the American College of Cardiology 61, no. 10_S (2013).

 

  1. *Guo K, Martucci G, Leask R, Marelli A, *Shimony A, Langleben D, Afilalo J, Therrien J. Anatomical Considerations for the Development of a new Transcatheter Aortopulmonary Shunt Device in Patients with Severe Pulmonary Arterial Hypertension. J Am Coll Cardiol 2013;61:E1249.

 

  1. *Mylotte Darren, Dinela Rushani, Liming Guo, Mohammed Kaouache, Kenneth Guo, Judith Therrien, Giuseppe Martucci, Andrew Mackie, and Ariane Marelli. “Bacterial Endocarditis in Patients with Adult Congenital Heart Disease: The Impact of Lesion type and Recent Valve Replacement Surgery.” Journal of the American College of Cardiology 61, no. 10_S (2013).

 

  1. *Addetia Karima, *Alex Zhai, Aaron Leong, Amal Bessissow, Avi Shimony, David Langleben, and Judith Therrien. “Right Ventricular End-Diastolic Wall Stress Predicts Survival in Patients With Pulmonary Arterial Hypertension.” CHEST Journal 144, no. 4_MeetingAbstracts (2013): 869A-869A.

 

  1. *Mylotte Darren, Louise Pilote, Raluca Ionescu-Ittu, Michal Abrahamowicz, Paul Khairy, Judith Therrien, Andrew S. Mackie, and Ariane Marelli. “Specialized adult congenital heart disease care: the impact of policy on mortality.” Circulation (2014): CIRCULATION AHA-113.

 

  1. *Lanz Jonas, James Brophy, Judith Therrien, Mohammed Kaouache, and Ariane Marelli. “Incidence and Predictors of Stroke in Adults with Congenital Heart Disease: The Impact of Heart Failure.” Journal of the American College of Cardiology 63, no. 12_S (2014).

 

  1. *Nanci Vanessa, Judith Therrien, Mohammed Kaouache, Darren Mylotte, and Ariane Marelli. “Predictors of Emergency Department Visits Among Adult Congenital Heart Disease Patients: A Population-Based Analysis.” Journal of the American College of Cardiology 63, no. 12_S (2014).

 

  1. L. Leask, *S. Cooper, J. Therrien, R. Mongrain, K. Guo, G. Martucci; Transcatheter Aorta Pulmonary Shunt (TAPS) McGill, Montreal, QC, CANADA. World Congress of Biomechanics, Boston MA, July 6-11, 2014

 

  1. Cohen Sarah, Therrien J, Marelli A. “Exposure to Low-Dose Ionizing Radiation From Cardiac Procedures and Risk of Malignancy in Adults with Congential Heart Disease” Circulation 2016

 

  1. Coher Sarah, Therrien Judith, Marelli A. “Congestive Heart Failure in Audlts with Congenital Heart Disease: what predicts it and how does it affect mortality?” Circulation 2016

 

  1. Golderg C, Therrien J, Marelli A. “Long term Cardiac Follow up with Severe Congenital Heart Disease: Are Care Gaps Associated with an Increase Probability of Mortality”, Circulation 2016.